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CT-Assessed Dysanapsis and Airflow Obstruction in Early and Mid Adulthood

Published:August 11, 2021DOI:https://doi.org/10.1016/j.chest.2021.08.038
      Dysanapsis refers to an anthropometric mismatch of airway tree caliber that was initially inferred from maximal expiratory airflow variation among healthy adults.
      • Green M.
      • Mead J.
      • Turner J.M.
      Variability of maximum expiratory flow-volume curves.
      CT-assessed dysanapsis among older adults is a major risk factor for COPD independent of standard risk factors (ie, tobacco exposures, air pollutants, asthma).
      • Smith B.M.
      • Kirby M.
      • Hoffman E.A.
      • et al.
      Association of dysanapsis with chronic obstructive pulmonary disease among older adults.
      Although the mechanisms of dysanapsis are uncertain, factors that affect airway tree growth early in life
      • Green M.
      • Mead J.
      • Turner J.M.
      Variability of maximum expiratory flow-volume curves.
      ,
      • Martin T.R.
      • Feldman H.A.
      • Fredberg J.J.
      • Castile R.G.
      • Mead J.
      • Wohl M.E.
      Relationship between maximal expiratory flows and lung volumes in growing humans.
      and factors that affect airway tree homeostasis later in life have been implicated.
      • Rawlins E.L.
      • Okubo T.
      • Xue Y.
      • et al.
      The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.
      ,
      • Ito K.
      • Barnes P.J.
      COPD as a disease of accelerated lung aging.
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