Advertisement

Differential Effect of School-Based Pollution Exposure in Children With Asthma Born Prematurely

      Asthma or asthma-like disease is highly prevalent in children born prematurely; however, it lacks the typical features of high rates of atopy or family history that characterize childhood asthma.
      • Halvorsen T.
      • Skadberg B.T.
      • Eide G.E.
      • Roksund O.
      • Aksnes L.
      • Oymar K.
      Characteristics of asthma and airway hyper-responsiveness after premature birth.
      Furthermore, aside from exposure to tobacco smoke,
      • Palta M.
      • Sadek-Badawi M.
      • Sheehy M.
      • et al.
      Respiratory symptoms at age 8 years in a cohort of very low birth weight children.
      little is known about how premature children with asthma may react to typical environmental triggers for asthma. A study by Strickland et al
      • Strickland M.J.
      • Klein M.
      • Flanders W.D.
      • et al.
      Modification of the effect of ambient air pollution on pediatric asthma emergency visits: susceptible subpopulations.
      found ambient air pollution exposure differentially led to asthma morbidity in children born prematurely. We previously found that classroom exposure to nitrogen dioxide (NO2) was associated with increased airflow obstruction in school-aged children with asthma in the School Inner City Asthma Study (SICAS).
      • Gaffin J.M.
      • Hauptman M.
      • Petty C.R.
      • et al.
      Nitrogen dioxide exposure in school classrooms of inner-city children with asthma.
      Here, we further aimed to test the hypothesis that exposure to poor indoor air quality disproportionately affects asthma morbidity in children born prematurely.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic and Personal

      Subscribe:

      Subscribe to CHEST
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Halvorsen T.
        • Skadberg B.T.
        • Eide G.E.
        • Roksund O.
        • Aksnes L.
        • Oymar K.
        Characteristics of asthma and airway hyper-responsiveness after premature birth.
        Pediatr Allergy Immunol. 2005; 16: 487-494
        • Palta M.
        • Sadek-Badawi M.
        • Sheehy M.
        • et al.
        Respiratory symptoms at age 8 years in a cohort of very low birth weight children.
        Am J Epidemiol. 2001; 154: 521-529
        • Strickland M.J.
        • Klein M.
        • Flanders W.D.
        • et al.
        Modification of the effect of ambient air pollution on pediatric asthma emergency visits: susceptible subpopulations.
        Epidemiology. 2014; 25: 843-850
        • Gaffin J.M.
        • Hauptman M.
        • Petty C.R.
        • et al.
        Nitrogen dioxide exposure in school classrooms of inner-city children with asthma.
        J Allergy Clin Immunol. 2018; 141: 2249-2255.e2
        • Phipatanakul W.
        • Bailey A.
        • Hoffman E.B.
        • et al.
        The school inner-city asthma study: design, methods, and lessons learned.
        J Asthma. 2011; 48: 1007-1014
        • Hankinson J.L.
        • Odencrantz J.R.
        • Fedan K.B.
        Spirometric reference values from a sample of the general U.S. population.
        Am J Respir Crit Care Med. 1999; 159: 179-187
        • Lum S.
        • Kirkby J.
        • Welsh L.
        • Marlow N.
        • Hennessy E.
        • Stocks J.
        Nature and severity of lung function abnormalities in extremely pre-term children at 11 years of age.
        Eur Respir J. 2011; 37: 1199-1207
        • Fawke J.
        • Lum S.
        • Kirkby J.
        • et al.
        Lung function and respiratory symptoms at 11 years in children born extremely preterm: the EPICure study.
        Am J Respir Crit Care Med. 2010; 182: 237-245
        • Collaco J.M.
        • Morrow M.
        • Rice J.L.
        • McGrath-Morrow S.A.
        Impact of road proximity on infants and children with bronchopulmonary dysplasia.
        Pediatr Pulmonol. 2020; 55: 369-375