Advertisement

Histopathological Comparison of Endobronchial Biopsies from Different Pulmonary Lobes of Severe Asthmatic Patients

      Fiber-optic bronchoscopy with endobronchial biopsy (EBB) has become an important tool for accurate diagnosis and treatment selection in airway diseases. In a recent study, histopathological EBB findings revealed an overlapping COPD-asthma phenotype; however, the challenge of selecting the proper lung region for biopsy was raised because dissimilarities in the histology of different lobes could affect the homogeneity of samples.
      • Papakonstantinou E.
      • Savic S.
      • Siebeneichler A.
      • et al.
      A pilot study to test the feasibility of histological characterisation of asthma-COPD overlap.
      In the present study, we compared histopathological features among different lung lobes of severe asthmatics.
      To read this article in full you will need to make a payment
      Subscribe to CHEST
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Papakonstantinou E.
        • Savic S.
        • Siebeneichler A.
        • et al.
        A pilot study to test the feasibility of histological characterisation of asthma-COPD overlap.
        Eur Respir J. 2019; 53: 1801941
        • Grendelmeier P.
        • Tamm M.
        • Jahn K.
        • Pflimlin E.
        • Stolz D.
        Flexible bronchoscopy with moderate sedation in COPD: a case-control study.
        Int J Chron Obstruct Pulmon Dis. 2017; 12: 177-187
        • Grendelmeier P.
        • Tamm M.
        • Pflimlin E.
        • Stolz D.
        Propofol sedation for flexible bronchoscopy: a randomised, noninferiority trial.
        Eur Respir J. 2014; 43: 591-601
        • Schlatter L.
        • Pflimlin E.
        • Fehrke B.
        • Meyer A.
        • Tamm M.
        • Stolz D.
        Propofol versus propofol plus hydrocodone for flexible bronchoscopy: a randomised study.
        Eur Respir J. 2011; 38: 529-537
        • Ijpma G.
        • Panariti A.
        • Lauzon A.M.
        • Martin J.G.
        Directional preference of airway smooth muscle mass increase in human asthmatic airways.
        Am J Physiol Lung Cell Mol Physiol. 2017; 312: L845-L854
        • Kuwano K.
        • Bosken C.H.
        • Pare P.D.
        • Bai T.R.
        • Wiggs B.R.
        • Hogg J.C.
        Small airways dimensions in asthma and in chronic obstructive pulmonary disease.
        Am Rev Respir Dis. 1993; 148: 1220-1225
        • Elliot J.G.
        • Noble P.B.
        • Mauad T.
        • et al.
        Inflammation-dependent and independent airway remodelling in asthma.
        Respirology. 2018; 23: 1138-1145
        • Benayoun L.
        • Druilhe A.
        • Dombret M.C.
        • Aubier M.
        • Pretolani M.
        Airway structural alterations selectively associated with severe asthma.
        Am J Respir Crit Care Med. 2003; 167: 1360-1368
        • Bourdin A.
        • Neveu D.
        • Vachier I.
        • Paganin F.
        • Godard P.
        • Chanez P.
        Specificity of basement membrane thickening in severe asthma.
        J Allergy Clin Immunol. 2007; 119: 1367-1374
        • Pretolani M.
        • Dombret M.C.
        • Knap D.
        • et al.
        Reduction of airway smooth muscle mass by bronchial thermoplasty in patients with severe asthma.
        Am J Respir Crit Care Med. 2014; 190: 1452-1454