Abbrevationss:AQLQS (asthma quality-of-life questionnaire with standardized activities), CI (confidence interval), ICS (inhaled corticosteroid), ICS+ (inhaled corticosteroid plus at least one other long-term asthma-control medication), PPI (proton-pump inhibitor)
Gibson PG, Henry RL, Coughlan JL. Gastro-esophageal reflux treatment for asthma in adults and children. Cochrane Database Syst Rev (database online). Issue 2, 2002
- Asthmatics with gastroesophageal reflux: long term results of a randomized trial of medical and surgical antireflux therapies.Am J Gastroenterol. 2003; 98: 987-999
- Validation of a standardized version of the asthma quality of life questionnaire.Chest. 1999; 115: 1265-1270
- Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease: the Practice Parameters Committee of the American College of Gastroenterology.Am J Gastroenterol. 1999; 94: 1434-1442
- National Asthma Education and Prevention Program.Expert panel report II: guidelines for the diagnosis and management of asthma. 1997; (April National Heart, Lung, and Blood Institute. Bethesda, MD: NIH Publication No. 97–4051)
- Reference spirometric values using techniques and equipment that meet ATS recommendations.Am Rev Respir Dis. 1981; 123: 659-664
- A controlled assessment of an asthma self-management plan involving a budesonide dose regimen: OPTIONS Research Group.Eur Respir J. 1996; 9: 886-892
- Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial.Lancet. 2001; 357: 2007-2011
- Effect of inhaled formoterol and budesonide on exacerbations of asthma: Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.N Engl J Med. 1997; 337: 1405-1411
- Asthma and gastroesophageal reflux: acid suppressive therapy improves asthma outcome.Am J Med. 1996; 100: 395-405
- Evaluation of different inhaled combination therapies (EDICT): a randomised, double-blind comparison of SeretideTM (50/250 μg bd Diskus vs. formoterol (12 μg bd) and budesonide (800 μg bd) given concurrently (both via Turbuhaler) in patients with moderate-to-severe asthma.Respir Med. 2002; 96: 851-861
- The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics.Eur Respir J. 2001; 18: 254-261
National Institutes of Health. Global initiative for asthma. 2002 National Institutes of Health. Bethesda, MD: NIH Publication No 02–3659
- Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA).BMJ. 2000; 320: 1368-1373
- Similarities and differences in asthma and chronic obstructive pulmonary disease exacerbations.Proc Am Thorac Soc. 2004; 1: 73-79
- Determining a minimal important change in a disease-specific quality of life questionnaire.J Clin Epidemiol. 1994; 47: 81-87
- Omeprazole improves peak expiratory flow rate and quality of life in asthmatics with gastroesophageal reflux.Am J Gastroenterol. 1998; 93: 1060-1063
- 24-hour pH testing in asthmatics: Respiratory symptom correlation with esophageal acid events.Chest. 1999; 115: 654-659
- Gastroesophageal reflux in asthmatics: a double-blind, placebo-controlled crossover study with omeprazole.Chest. 1999; 116: 1257-1264
- The cost-effectiveness of strategies to assess gastroesophageal reflux as an exacerbating factor in asthma.Am J Gastroenterol. 1999; 94: 1472-1480
- Medical and surgical treatment of nonallergic asthma associated with gastroesophageal reflux.Chest. 1991; 99: 1330-1335
- Effective intra-oesophageal acid suppression in patients with gastro-oesophageal reflux disease: lansoprazole vs. pantoprazole.Aliment Pharmacol Ther. 2003; 17: 235-241
- Effect of four lansoprazole dose levels and one dosage regimen of omeprazole on 24-hour intragastric pH in healthy patients.Methods Find Exp Clin Pharmacol. 1995; 17: 489-495
A list of Participating Investigators of the Lansoprazole Asthma Study Group is located in the Appendix.
Presented in part at the annual meetings of the European Respiratory Society in Stockholm, Sweden, September 15, 2002 and the American College of Gastroenterology in Seattle, WA, October 21, 2002.
Dr. Littner is a paid consultant for TAP Pharmaceutical Products, Inc. Dr. Ballard and Mrs. Samra are employees of TAP Pharmaceutical Products, Inc. Dr. Huang is an employee of Abbott Laboratories. Drs. Littner and Leung received grant support for this study from TAP Pharmaceutical Products, Inc.
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