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Rebuttal From Dr. Guyatt et al

      It is unfortunate that Dr. Tobin
      • Tobin MJ
      Evidence-based medicine has a sound scientific base.
      (see page 1071) relied largely on early writings about evidence-based medicine (EBM). For instance, when considering the EBM approach to quality of evidence (Table 2 in the editorial by Tobin
      • Tobin MJ
      Evidence-based medicine has a sound scientific base.
      ), he uses a 1995 publication rather than the most recent approaches.
      • Atkins D
      • Best D
      • Briss PA
      • et al.
      Grading quality of evidence and strength of recommendations.
      • Schunemann HJ
      • Jaeschke R
      • Cook DJ
      • et al.
      An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations.
      • Guyatt G
      • Vist G
      • Falck-Ytter Y
      • et al.
      An emerging consensus on grading recommendations?.
      • Guyatt G
      • Gutterman D
      • Baumann MH
      • et al.
      Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians task force.
      In our response, we will use the system of evaluating evidence and developing recommendations that has been proposed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group
      • Atkins D
      • Best D
      • Briss PA
      • et al.
      Grading quality of evidence and strength of recommendations.
      • Schunemann HJ
      • Jaeschke R
      • Cook DJ
      • et al.
      An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations.
      • Guyatt G
      • Vist G
      • Falck-Ytter Y
      • et al.
      An emerging consensus on grading recommendations?.
      and the American College of Chest Physicians,
      • Guyatt G
      • Gutterman D
      • Baumann MH
      • et al.
      Grading strength of recommendations and quality of evidence in clinical guidelines: report from an American College of Chest Physicians task force.
      which reflects the current thinking on EBM. We quote Dr. Tobin's misguided notions about EBM; what EBM actually maintains follows the quotations.
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