Advertisement

Effects of a Bronchoprovocation Challenge Test With Cigarette Sidestream Smoke on Sensitive and Healthy Adults

      In order to study the acute effects of environmental tobacco smoke on lung function, a cigarette sidestream smoke provocation test (analogous to a nonspecific bronchial provocation test) was performed. Ten persons with airways hyperreactive to methacholine and ten normoreactive persons were tested. A dose-response relationship was found for symptoms. The lung function of the normoreactive persons was not altered by short-time inhalation of sidestream smoke. The hyperreactive subjects, however, experienced significant decreases in FEV1, FVC, and MEF50. The decrease was most pronounced after the lowest dose of 2 ppm smoke-induced CO, leading to a mean (all of 6.3 percent in FEV1. Five of ten subjects with hyperreactive airways showed a decrease in FEV1 of more than 10 percent during the sidestream smoke provocation, one of them a decrease of over 20 percent after inhalation of 16 ppm CO sidestream smoke. We conclude that even short exposure to low concentrations of cigarette sidestream smoke causes significant impairment of lung function in sensitive persons.
      To read this article in full you will need to make a payment
      Subscribe to CHEST
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      REFERENCES

        • Muramatsu T
        • Weber A
        • Muramatsu S
        • Ackermann F
        An experimental study on irritation and annoyance due to passive smoking.
        Int Arch Occup Environ Health. 1983; 51: 305-317
        • Shephard RJ
        • Ponsford E
        • LaBarre R
        • Basu PK
        Subjective reactions to passive cigarette smoke exposure: effect of cigarette smoke on the eyes and airways.
        Int Arch Occup Environ Health. 1979; 43: 135-144
        • Speer F
        Tobacco and the nonsmokers.
        Arch Environ Health. 1968; 16: 443-446
        • Weber A
        Acute effects of environmental tobacco smoke.
        Eur J Respir Dis. 1983; 65: 98-108
        • Pimm P
        • Shephard RJ
        • Silverman F
        Physiological effects of acute passive exposure to cigarette smoke.
        Arch Environ Health. 1978; 33: 201-203
        • Shephard RJ
        • Collins R
        • Silverman F
        Responses of exercising subjects to acute ‘passive’ cigarette smoke exposure.
        Environ Res. 1979; 19: 279-291
        • Ben-Hassine MR
        • Ben-Miled MT
        • el-Gharbi T
        • Ben-Ayed N
        Le tabagisme passif chez l'asthmatique.
        Tunis Med. 1984; 62: 251-254
        • Shephard RG
        • Collins R
        • Silverman F
        Passive exposure of asthmatic subjects to cigarette smoke.
        Environ Res. 1979; 20: 392-402
        • Urch RB
        • Silverman F
        • Corey P
        • Shephard RJ
        • Cole P
        • Goldsmith LJ
        Does suggestibility modify acute reactions to passive cigarette smoke exposure?.
        Environ Res. 1988; 47: 34-47
        • Wiedemann HP
        • Mahler DA
        • Loke J
        • Virgulgo JA
        • Snyder P
        • Mattay RA
        Acute effects of passive smoking on lung function and airway reactivity in asthmatic subjects.
        Chest. 1986; 89: 180-185
        • Dahms TE
        • Bolin JF
        • Slavin RG
        Passive smoking: effects on bronchial asthma.
        Chest. 1981; 80: 530-534
        • Knight A
        • Breslin AB
        Passive cigarette smoking and patients with asthma.
        Med J Aust. 1985; 142: 194-195
        • Lehrer SB
        • Stankus RP
        • Salvaggio JE
        Tobacco smoke sensitivity: a result of allergy?.
        Ann Allergy. 1986; 56: 369-381
        • Stankus RP
        • Menon PK
        • Rando RJ
        • Glindmeyer H
        • Salvaggio JE
        • Lehrer SB
        Cigarette smoke-sensitive asthma: challenge studies.
        J Allergy Clin Immunol. 1988; 82: 331-338
        • Hartmann AL
        • Weber A
        • Danuser B
        Passivrauchen: Akute Effekte auf die Lungenfunktion sensibler Personen.
        Soz Praventivmed. 1987; 32: 299-302
        • Josephs LK
        • Gregg I
        • Mullee MA
        • Holgate ST
        Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma.
        Am Rev Respir Dis. 1989; 140: 350-357
        • Cockcroft DW
        • Killian DN
        • Mellon JJA
        • Hargreave FE
        Bronchial reactivity to inhaled histamine: a method and clinical survey.
        Clin Allergy. 1977; 7: 235-243
        • Klein RC
        • Salvaggio JE
        Nonspecificity of the bronchoconstricting effect of histamine and acetyl-beta-methylcholine in patients with obstructive airway disease.
        J Allergy. 1966; 37: 158-168
        • Empey DW
        • Laitinen LA
        • Jacobs L
        • Gold WM
        • Nadel JA
        Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection.
        Am Rev Respir Dis. 1976; 113: 131-139
        • Rijcken B
        • Schouten JP
        • Weiss ST
        • Speizer FE
        • Van der Lende R
        The association of airway responsiveness to respiratory symptom prevalence and to pulmonary function in a random population sample.
        Bull Eur Physiopathol Respir. 1987; 23: 291-294
        • Knudson RJ
        • Slatin RC
        • Lebowitz MD
        • Burrows B
        The maximal expiratory flow-volume curve: normal standards, variability and effects of age.
        Am Rev Respir Dis. 1976; 113: 587-600
        • Wolf CH
        Die bronchiale Reagibilitätsprüfung mit Histamin.
        Prax Klin Pneumol. 1987; 41: 324-327
        • Danuser B
        • Weber A
        • Hartmann AL
        • Krueger H
        Generation and characterization of cigarette sidestream smoke.
        J Aerosol Sci. 1990; 21: 447-450
        • Enarson DA
        • Schulzer M
        • Vedal S
        • Chan-Yeung M
        Summarizing methacholine bronchoprovocation data in epidemiological surveys.
        Bull Eur Physiopathol Respir. 1987; 23: 387-389
        • Urch RB
        • Silverman F
        • Corey P
        • Shephard RJ
        Pulmonary function responses to passive cigarette smoke exposure.
        in: Wallinshaw DS Indoor air quality in cold climates: hazards and abatement measures. Air Pollution Control Association, Pittsburgh, Penn1986: 48-61
        • Lebowitz MD
        • Quackenboss J
        • Camilli AE
        • Bronnimann D
        • Holberg CJ
        • Boyer B
        The epidemiological importance of intraindividual changes in objective pulmonary responses.
        Eur J Epidemiol. 1987; 3: 390-398
        • Weber A
        • Fischer T
        Passive smoking at work.
        Int Arch Occup Environ Health. 1980; 47: 209-221
        • Sterling TD
        • Dimich H
        • Kobayashi D
        Indoor byproduct levels of tobacco smoke: a critical review of the literature.
        JAPCA. 1982; 32: 250-259
        • Weber A
        • Fischer T
        Schadstoffkonzentrationen im Blasfeld von Rauchern.
        Int Arch Occup Environ Health. 1983; 53: 47-50
        • Menon P
        • Rando RJ
        • Stankus RP
        • Salvaggio JE
        • Lehrer SB
        Passive cigarette smoke-challenge studies: increase in bronchial hyperreactivity.
        J Allergy Clin Immunol. 1992; 89: 560-566
      1. Fischer A. Passivrauchen: Ausmass und Wirkung der Luftverunreinigung durch Tabakrauch unter experimentellen Bedingungen und in Feldversuchen. Diss ETH, 1979, Nr. 6298

      Linked Article

      • Environmental Tobacco Smoke and Asthma
        ChestVol. 103Issue 2
        • Preview
          Many cities now oblige smokers to leave enclosed spaces, such as office buildings and bus and train stations, if they wish to indulge their addiction. There can be little argument that the accumulation of stale tobacco smoke is unpleasant and annoying to both the nonsmoker and the ex-smoker, and this will undoubtedly remain the main reason why a smoke-free environment is guaranteed in public places. Nevertheless, there is also some evidence that the concentrations of smoke likely in the absence of legislation have adverse consequences for health, including small but unacceptable increases in the risks of bronchial carcinoma, chronic obstructive lung disease, and coronary heart disease.
        • Full-Text
        • PDF