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Chicken Soup Inhibits Neutrophil Chemotaxis In Vitro

      Chicken soup has long been regarded as a remedy forsymptomatic upper respiratory tract infections. As it is likely thatthe clinical similarity of the diverse infectious processes that canresult in “colds” is due to a shared inflammatory response, aneffect of chicken soup in mitigating inflammation could account for itsattested benefits. To evaluate this, a traditional chicken soup wastested for its ability to inhibit neutrophil migration using thestandard Boyden blindwell chemotaxis chamber assay withzymosan-activated serum and fMet-Leu-Phe as chemoattractants. Chickensoup significantly inhibited neutrophil migration and did so in aconcentration-dependent manner. The activity was present in anonparticulate component of the chicken soup. All of the vegetablespresent in the soup and the chicken individually had inhibitoryactivity, although only the chicken lacked cytotoxic activity. Interestingly, the complete soup also lacked cytotoxic activity. Commercial soups varied greatly in their inhibitory activity. Thepresent study, therefore, suggests that chicken soup may contain anumber of substances with beneficial medicinal activity. A mildanti-inflammatory effect could be one mechanism by which the soup couldresult in the mitigation of symptomatic upper respiratory tractinfections.

      Key words:

      Abbreviations::

      fMLP (= fMet-Leu-Phe), HBSS (= Hank's balanced salt solution), ZAS (= zymosan-activatedserum)
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      References

        • Rosner F
        Therapeutic efficacy of chicken soup.
        Chest. 1980; 78: 672-674
        • Rosner F
        The medical writings of Moses Maimonides.
        NY State J Med. 1973; 73: 2185-2190
        • Rosner F
        • Muntner S
        The medical aphorisms of Moses Maimonides. Bloch Publishing for Yeshiva University Press, New York, NY1973
        • Muntner S
        The medical writings of Moses Maimonides: treatise on asthma (vol 115). Lippincott, Philadelphia, PA1963: 18-2042 (68)
        • Saketkhoo K
        • Januszkiewics BS
        • Sackner MA
        Effects of drinking hot water, cold water and chicken soup on nasal mucus velocity and nasal airflow resistance.
        Chest. 1978; 74: 408-410
        • Caroline NL
        • Schwartz H
        Chicken soup rebound and relapse of pneumonia: report of a case.
        Chest. 1975; 67: 215-216
        • Lewis B
        The joys and benefits of chicken soup.
        The Jerusalem Post. 1994; : 7-8
        • Turner RB
        Epidemiology, pathogenesis, and treatment of the common cold.
        Ann Allergy Asthma Immunol. 1997; 78: 531-539
        • Makela MJ
        • Puhakka T
        • Ruuskanen O
        • et al.
        Viruses and bacteria in the etiology of the common cold.
        J Clin Microbiol. 1998; 36: 539-542
        • Engel JP
        Viral upper respiratory infections.
        Semin Respir Infect. 1995; 10: 3-13
        • Johnston SL
        • Papi A
        • Bates PJ
        • et al.
        Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium.
        J Immunol. 1998; 160: 6172-6181
        • Zhu Z
        • Tang W
        • Gwaltney JM
        • et al.
        Rhinovirus stimulation of interleukin-8 in vivo and in vitro : role of NF-kappaB.
        Am J Physiol. 1997; 273: L814-L824
        • Yuta A
        • Doyle WJ
        • Gaumond E
        • et al.
        Rhinovirus infection induces mucus hypersecretion.
        Am J Physiol. 1998; 274: L1017-L1023
        • Hendley JO
        The host response, not the virus, causes the symptoms of the common cold.
        Clin Infect Dis. 1998; 26: 847-848
        • Turner RB
        • Weingand KW
        • Yeh CH
        • et al.
        Association beween interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds.
        Clin Infect Dis. 1998; 26: 840-846
        • Proud D
        • Gwaltney JM
        • Hendley JO
        • et al.
        Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds.
        J Infect Dis. 1994; 169: 1007-1013
        • Teran IM
        • Johnston SL
        • Schroder JM
        • et al.
        Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma.
        Am J Respir Crit Care Med. 1997; 155: 1362-1366
        • Sommerhoff CP
        • Nadel JA
        • Basbaum CB
        • Caughey GH
        Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.
        J Clin Invest. 1990; 85: 682-689
        • Kunstadter P
        • Kunstadter SL
        • Podhisita C
        • Leepreecha P
        Demographic variables in fetal and child mortality: Hmong in Thailand.
        Soc Sci Med. 1993; 36: 1109-1120
        • Soffer A
        Chicken soup, sippy milk diets and bed rest for hepatitis.
        Chest. 1975; 67: 214-215
        • Soffer A
        Chicken soup or laetrile: which would you prescribe?.
        Arch Intern Med. 1977; 137: 994-995
        • Klempner MS
        • Dinarello CA
        • Gallin JI
        Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.
        J Clin Invest. 1978; 61: 1330-1336
        • Harvath L
        • Falk W
        • Leonard EJ
        Rapid quantitation of neutrophil chemotaxis: use of a polyvinylpyrrolidone-free polycarbonate membrane in a multiwell assembly.
        J Immunol Methods. 1980; 37: 39-45
        • Shaw JO
        • Henson PM
        • Henson J
        • et al.
        Lung inflammation induced by complement-derived chemotactic fragments in the alveolus.
        Lab Invest. 1980; 42: 547-558
        • Dorsch W
        • Wagner H
        New antiasthmatic drugs from traditional medicine?.
        Int Arch Allergy Appl Immunol. 1991; 94: 262-265
        • Abbey M
        • Noakes M
        • Nestle PJ
        Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidized low-density lipoproteins.
        J Am Diet Assoc. 1995; 95: 671-675
        • Potter JD
        • Steinmetz K
        Vegetables, fruit and phytoestrogens as preventive agents.
        IARC Sci Publ. 1996; 139: 61-90
        • Saff RH
        • Fink JN
        Anaphylaxis to chicken soup: a case report and a brief history of the chicken in medicine.
        J Allergy Clin Immunol. 1992; 89: 1061-1062
        • Spanel S
        Winter cold? Chicken soup to the rescue.
        St. Louis Times. February 1995; : 8
        • Terkeltaub RA
        • Sklar LA
        • Mueller H
        Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.
        J Immunol. 1990; 144: 2719-2724
        • Packman R
        The chicken soup controversy [letter].
        Chest. 1975; 68: 605
        • Leiberman A
        Unstrained chicken soup [letter].
        Chest. 1980; 77: 128
        • Ekberg O
        • Feinberg M
        Clinical and demographic data in 75 patients with near-fatal choking episodes.
        Dysphagia. 1992; 7: 205-208
        • Avital A
        • Springer C
        • Meyer JJ
        • et al.
        Hollow bone in the bronchus or the danger of chicken soup.
        Respiration. 1992; 59: 62-63
        • Jujiwara P
        • Berry M
        • Hauger P
        • et al.
        Chicken soup hypernatremia.
        N Engl J Med. 1985; 313: 1161-1162
        • Lawrence DS
        The chicken soup controversy [letter].
        Chest. 1975; 68: 606
        • Toda Y
        • Takemura S
        • Morimoto T
        • et al.
        Relationship between HLA-DRBI genotypes and efficacy of oral type II collagen treatment using chicken cartilage soup in rheumatoid arthritis.
        Nihon Rinsho Meneki Gakkai Kaishi. 1997; 20: 44-51
        • Folkerts G
        • Nijkamp FP
        Virus-induced airway hyperresponsiveness: role of inflammatory cells and mediators.
        Am J Respir Crit Care Med. 1995; 151: 1666-1673
        • Ziment I
        Colds, coughs and nasal allergies.
        in: Practical pulmonary disease. Wiley, New York, NY1983: 51-79
        • Chu E
        Dangers of chicken soup.
        Pediatrics. 1986; 77: 785-786

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