Chicken Soup Inhibits Neutrophil Chemotaxis In Vitro

      Chicken soup has long been regarded as a remedy forsymptomatic upper respiratory tract infections. As it is likely thatthe clinical similarity of the diverse infectious processes that canresult in “colds” is due to a shared inflammatory response, aneffect of chicken soup in mitigating inflammation could account for itsattested benefits. To evaluate this, a traditional chicken soup wastested for its ability to inhibit neutrophil migration using thestandard Boyden blindwell chemotaxis chamber assay withzymosan-activated serum and fMet-Leu-Phe as chemoattractants. Chickensoup significantly inhibited neutrophil migration and did so in aconcentration-dependent manner. The activity was present in anonparticulate component of the chicken soup. All of the vegetablespresent in the soup and the chicken individually had inhibitoryactivity, although only the chicken lacked cytotoxic activity. Interestingly, the complete soup also lacked cytotoxic activity. Commercial soups varied greatly in their inhibitory activity. Thepresent study, therefore, suggests that chicken soup may contain anumber of substances with beneficial medicinal activity. A mildanti-inflammatory effect could be one mechanism by which the soup couldresult in the mitigation of symptomatic upper respiratory tractinfections.

      Key words:


      fMLP (= fMet-Leu-Phe), HBSS (= Hank's balanced salt solution), ZAS (= zymosan-activatedserum)
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