Rebuttal From Drs Mohr and Doerschug

  • Nicholas M. Mohr
    Correspondence
    Correspondence to: Nicholas M. Mohr, MD, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, 1008 RCP, Iowa City, IA 52242
    Affiliations
    Department of Emergency Medicine, Division of Critical Care, Department of Anesthesia, University of Iowa Carver College of Medicine, Iowa City, IA
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  • Kevin C. Doerschug
    Affiliations
    Division of Pulmonary Diseases, Critical Care and Occupational Medicine, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA
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      In their counterpoint editorial, Drs Drewry and Hotchkiss
      • Drewry AM
      • Hotchkiss RS
      Counterpoint: should antipyretic therapy be given routinely to febrile patients in septic shock? No.
      present a well-reasoned argument of why fever may benefit those with life-threatening infections. We agree with several of their points that likely merit little further discussion:
      • 1.
        Fever is an adaptive response and affords some host protection;
      • 2.
        Little evidence-based support exists for use of antipyretic medications to improve fever-associated morbidity and/or mortality; and
      • 3.
        Fever control in life-threatening infection merits further high-quality study.
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        Counterpoint: should antipyretic therapy be given routinely to febrile patients in septic shock? No.
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