Fever is an adaptive response and affords some host protection;
Little evidence-based support exists for use of antipyretic medications to improve fever-associated morbidity and/or mortality; and
Fever control in life-threatening infection merits further high-quality study.
- Counterpoint: should antipyretic therapy be given routinely to febrile patients in septic shock? No.Chest. 2013; 144: 1098-1101
- Antipyretic therapy in febrile critically ill adults: a systematic review and meta-analysis.J Crit Care. 2013; 28: 303-310
- Review Manager (RevMan) [computer program]. The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark2012
- Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study.Crit Care. 2012; 16: R33
- Fever control using external cooling in septic shock: a randomized controlled trial.Am J Respir Crit Care Med. 2012; 185: 1088-1095
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