The Homogeneous and Robust Clinical Phenotype of Severe Lung Injury

      Acute-onset severe lung injury, regardless of etiology or associated risk factors, is universally recognized in terms of its sameness. Patients with this condition share many similarities, including younger age, few comorbidities, recovery of lung function in those without preexisting lung disease, ICU-acquired weakness (ICUAW), and neuropsychologic dysfunction. These patients also share resilience and recovery from a profound, multisystem, and exuberant inflammatory response. These outcomes are robust over time and across different countries and investigators.
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