Advancing Respiratory Research

  • James P. Kiley
    Correspondence to: James P. Kiley, PhD, Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Two Rockledge Centre, 6701 Rockledge Dr, Ste 10042, MSC 7952, Bethesda, MD 20892-7952
    Division of Lung Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
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      Respiratory diseases remain a major public health problem in the United States and worldwide, with increasing morbidity and mortality. Substantial progress has been made to advance understanding of the basic mechanisms of lung disease and to optimize clinical management of patients with a range of respiratory diseases. Despite this progress, our knowledge of how to predict disease prior to symptoms, improve disease definition and subclassification, and target novel and new treatments in a more personalized manner still remains inadequate. This article highlights several future opportunities and challenges related to genomics and molecular characterization of lung disease, lung injury and repair, translational lung research, the microbiome, and sleep and circadian biology as potential frontiers to advance progress in respiratory biology in health and disease.
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      • Ahead of the Curve
        CHESTVol. 140Issue 2
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          In this issue of CHEST, we introduce a new section called “Ahead of the Curve.” The objective of the series is to offer our readers an edge in a fast-changing environment. We hope these articles will convey the excitement, anticipation, and uncertainty associated with novel ideas and innovation and with the introduction and application of new scientific discoveries, technologies, policies, and regulations. We expect that “Ahead of the Curve,” at its best, can present a reasoned futuristic picture of a changing landscape in pulmonary, critical care, and sleep medicine.
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